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Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep

Overview of attention for article published in Veterinary Research, March 2013
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Title
Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep
Published in
Veterinary Research, March 2013
DOI 10.1186/1297-9716-44-14
Pubmed ID
Authors

Hicham Filali, Enric Vidal, Rosa Bolea, Mercedes Márquez, Paola Marco, Antonia Vargas, Martí Pumarola, Inmaculada Martin-Burriel, Juan J Badiola

Abstract

The molecular pathogenic mechanisms of prion diseases are far from clear. Genomic analyses have revealed genetic biomarkers potentially involved in prion neuropathology in naturally scrapie-infected sheep, a good animal model of infectious prionopathies. However, these biomarkers must be validated in independent studies at different stages of the disease. The gene and protein expression profiles and protein distribution of six potential genetic biomarkers (i.e., CAPN6, COL1A2, COL3A1, GALA1, MT2A and MTNR1B) are presented here for both the early and terminal stages of scrapie in five different brain regions. Gene transcription changes were confirmed in the medulla oblongata, and the expression profiles were generally similar in other central nervous system regions. The changes were more substantial in clinical animals compared to preclinical animals. The expression of the CAPN6 protein increased in the spinal cord and cerebellum of the clinical and preclinical brains. The distribution of the GALA1 was identified in glial cells from the cerebellum of scrapie-infected animals, GALA1 protein expression was increased in clinical animals in the majority of regions, and the increase of MT2A was in agreement with previous reports. The downregulation of MTNR1B was especially marked in the Purkinje cells. Finally, although collagen genes were downregulated the protein immunostaining did not reveal significant changes between the scrapie-infected and control animals. In conclusion, this study of gene transcription and protein expression and distribution confirm CAPN6, GALA1, MTNR1B and MT2A as potential targets for further prion disease research.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 24%
Student > Ph. D. Student 5 24%
Professor 4 19%
Other 1 5%
Lecturer > Senior Lecturer 1 5%
Other 3 14%
Unknown 2 10%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 29%
Agricultural and Biological Sciences 6 29%
Biochemistry, Genetics and Molecular Biology 5 24%
Medicine and Dentistry 2 10%
Immunology and Microbiology 1 5%
Other 0 0%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2013.
All research outputs
#3,079,014
of 4,507,211 outputs
Outputs from Veterinary Research
#318
of 417 outputs
Outputs of similar age
#60,167
of 89,268 outputs
Outputs of similar age from Veterinary Research
#11
of 12 outputs
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So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.