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Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection

Overview of attention for article published in BMC Ecology and Evolution, March 2013
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Title
Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection
Published in
BMC Ecology and Evolution, March 2013
DOI 10.1186/1471-2148-13-62
Pubmed ID
Authors

Audrey Sabbagh, Julie Marin, Charlotte Veyssière, Emilie Lecompte, Sotiria Boukouvala, Estella S Poloni, Pierre Darlu, Brigitte Crouau-Roy

Abstract

The arylamine N-acetyltransferases (NATs) are a unique family of enzymes widely distributed in nature that play a crucial role in the detoxification of aromatic amine xenobiotics. Considering the temporal changes in the levels and toxicity of environmentally available chemicals, the metabolic function of NATs is likely to be under adaptive evolution to broaden or change substrate specificity over time, making NATs a promising subject for evolutionary analyses. In this study, we trace the molecular evolutionary history of the NAT gene family during the last ~450 million years of vertebrate evolution and define the likely role of gene duplication, gene conversion and positive selection in the evolutionary dynamics of this family.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Researcher 7 18%
Student > Bachelor 3 8%
Student > Master 3 8%
Student > Postgraduate 2 5%
Other 6 15%
Unknown 11 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 28%
Agricultural and Biological Sciences 10 25%
Medicine and Dentistry 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Unspecified 1 3%
Other 3 8%
Unknown 10 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2013.
All research outputs
#16,721,717
of 25,373,627 outputs
Outputs from BMC Ecology and Evolution
#2,818
of 3,714 outputs
Outputs of similar age
#129,231
of 207,690 outputs
Outputs of similar age from BMC Ecology and Evolution
#52
of 74 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,690 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.