Title |
Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection
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Published in |
BMC Ecology and Evolution, March 2013
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DOI | 10.1186/1471-2148-13-62 |
Pubmed ID | |
Authors |
Audrey Sabbagh, Julie Marin, Charlotte Veyssière, Emilie Lecompte, Sotiria Boukouvala, Estella S Poloni, Pierre Darlu, Brigitte Crouau-Roy |
Abstract |
The arylamine N-acetyltransferases (NATs) are a unique family of enzymes widely distributed in nature that play a crucial role in the detoxification of aromatic amine xenobiotics. Considering the temporal changes in the levels and toxicity of environmentally available chemicals, the metabolic function of NATs is likely to be under adaptive evolution to broaden or change substrate specificity over time, making NATs a promising subject for evolutionary analyses. In this study, we trace the molecular evolutionary history of the NAT gene family during the last ~450 million years of vertebrate evolution and define the likely role of gene duplication, gene conversion and positive selection in the evolutionary dynamics of this family. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 20% |
Researcher | 7 | 18% |
Student > Bachelor | 3 | 8% |
Student > Master | 3 | 8% |
Student > Postgraduate | 2 | 5% |
Other | 6 | 15% |
Unknown | 11 | 28% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 11 | 28% |
Agricultural and Biological Sciences | 10 | 25% |
Medicine and Dentistry | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Unspecified | 1 | 3% |
Other | 3 | 8% |
Unknown | 10 | 25% |