Title |
Optimal enumeration of state space of finitely buffered stochastic molecular networks and exact computation of steady state landscape probability
|
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Published in |
BMC Systems Biology, March 2008
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DOI | 10.1186/1752-0509-2-30 |
Pubmed ID | |
Authors |
Youfang Cao, Jie Liang |
Abstract |
Stochasticity plays important roles in many molecular networks when molecular concentrations are in the range of 0.1 muM to 10nM (about 100 to 10 copies in a cell). The chemical master equation provides a fundamental framework for studying these networks, and the time-varying landscape probability distribution over the full microstates, i.e., the combination of copy numbers of molecular species, provide a full characterization of the network dynamics. A complete characterization of the space of the microstates is a prerequisite for obtaining the full landscape probability distribution of a network. However, there are neither closed-form solutions nor algorithms fully describing all microstates for a given molecular network. |
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