RT @_aacw: Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 rando…
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Plasma IL-18 is associated with increased mortality in ARDS, and may predict those who respond to simvastatin. Prospective evaluation and mechanistic studies needed ... +/- another simvastatin study😬 Paper below in @Crit_Care with @dfmcauley @msh_manu @ce
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@doc_matt_jacko @DavidSapsford @ICS_updates I think this data (https://t.co/5dJSKbivFZ), and previous, from our group @dfmcauley might suggest the population to target with simvastatin are those with higher baseline inflammation, e.g. high IL-18 or hyperin
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Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial : https://t.co/q5hNEu0i0D @_aboyle #SOA22