Title |
Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure
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Published in |
BMC Pulmonary Medicine, August 2008
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DOI | 10.1186/1471-2466-8-15 |
Pubmed ID | |
Authors |
Ali Reza Hosseini-khalili, Julian Thompson, Anthony Kehoe, Nicholas S Hopkinson, A Khoshbaten, Mohammad Reza Soroush, Steve E Humphries, Hugh Montgomery, Mostafa Ghanei |
Abstract |
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear. The Renin Angiotensin System (RAS) has been implicated in lung inflammatory and fibrotic responses. Genetic variation within the gene coding for the Angiotensin Converting Enzyme (ACE), specifically the Insertion/Deletion polymorphism (I/D), is associated with variable levels of ACE and with the severity of several acute and chronic respiratory diseases. We hypothesized that the ACE genotype might influence the severity of late respiratory complications of mustard gas exposure. |
X Demographics
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Country | Count | As % |
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United Kingdom | 3 | 75% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 3 | 23% |
Other | 2 | 15% |
Student > Bachelor | 1 | 8% |
Student > Master | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 31% |
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Agricultural and Biological Sciences | 1 | 8% |
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Social Sciences | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 31% |