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Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia

Overview of attention for article published in Journal of Translational Medicine, October 2016
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  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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1 X user
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1 Wikipedia page

Citations

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5 Dimensions

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17 Mendeley
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Title
Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia
Published in
Journal of Translational Medicine, October 2016
DOI 10.1186/s12967-016-1055-x
Pubmed ID
Authors

Xiaoyong Tan, Kai Yan, Meiping Ren, Ni Chen, Yongjie Li, Xin Deng, Liqun Wang, Rong Li, Mao Luo, Yong Liu, Yan Liu, Jianbo Wu

Abstract

Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive response to arterial occlusion. It is unknown whether the destabilization of blood vessels by Ang-2 can affect arteriogenesis and modulate mononuclear cell function. This study aimed to investigate the effects of Ang-2 on collateral artery growth. Hindlimb ischaemia model was produced in C57BL/6 mice by femoral artery ligation. Blood flow perfusion was measured using a laser Doppler perfusion imager quantitative RT-PCR analysis was applied to identify the level of angiogenic factors. After the induction of hindlimb ischaemia, blood flow recovery was impaired in mice treated with recombinant Ang-2 protein; this was accompanied by a reduction of peri-collateral macrophage infiltration. In addition, quantitative RT-PCR analysis revealed that Ang-2 treatment decreased monocyte chemotactic protein-1 (MCP-1), platelet-derived growth factor-BB (PDGF-BB) mRNA levels in ischaemic adductor muscles. Ang-2 can lead to macrophage M1/M2 polarization shift inhibition in the ischaemic muscles. Furthermore, Ang-2 reduced the in vitro inflammatory response in macrophages and vascular cells involved in arteriogenesis. Our results demonstrate that Ang-2 is essential for efficient arteriogenesis, which controls macrophage infiltration.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 18%
Student > Postgraduate 3 18%
Student > Doctoral Student 1 6%
Student > Master 1 6%
Professor 1 6%
Other 2 12%
Unknown 6 35%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 18%
Biochemistry, Genetics and Molecular Biology 2 12%
Medicine and Dentistry 2 12%
Computer Science 1 6%
Veterinary Science and Veterinary Medicine 1 6%
Other 2 12%
Unknown 6 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2020.
All research outputs
#7,245,857
of 22,896,955 outputs
Outputs from Journal of Translational Medicine
#1,161
of 4,008 outputs
Outputs of similar age
#110,135
of 314,045 outputs
Outputs of similar age from Journal of Translational Medicine
#13
of 70 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,008 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,045 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.