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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors
|
|---|---|
| Published in |
Journal for Immunotherapy of Cancer, October 2016
|
| DOI | 10.1186/s40425-016-0164-7 |
| Pubmed ID | |
| Authors |
MacLean Hall, Hao Liu, Mokenge Malafa, Barbara Centeno, Pamela J. Hodul, José Pimiento, Shari Pilon-Thomas, Amod A. Sarnaik |
| Abstract |
We evaluated whether tumor infiltrating lymphocytes (TIL) could be expanded from surgically resected tumors from pancreatic cancer patients. Tumors were resected from pancreatic cancer patients. Tumors were minced into fragments and cultured in media containing high dose interleukin-2 (IL-2) for up to 6 weeks. T cell phenotype, activation markers, and reactivity were measured. TIL expansion was measured in 19 patient samples. The majority of these TIL were CD4(+) T cells and were highly activated. Purified CD8(+) T cells produced IFN-γ in response to HLA-matched pancreatic tumor targets. PD-1 blockade and 4-1BB stimulation were demonstrated as effective strategies to improve effective TIL yield, including the production of tumor-reactive pancreatic TIL. TIL expanded from pancreatic tumors are functional and able to respond to pancreatic tumor associated antigens. PD-1 blockade, 41BB stimulation, and CD8(+) T cell enrichment are effective strategies to improve TIL yield and tumor reactivity. These results support the development of adoptive cell therapy strategies using TIL for the treatment of pancreatic cancer. |
Twitter Demographics
The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 2 | 40% |
| United States | 1 | 20% |
| Italy | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 219 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 20% |
| Student > Ph. D. Student | 26 | 12% |
| Student > Master | 25 | 11% |
| Student > Bachelor | 22 | 10% |
| Student > Postgraduate | 12 | 5% |
| Other | 34 | 16% |
| Unknown | 57 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 36 | 16% |
| Medicine and Dentistry | 36 | 16% |
| Biochemistry, Genetics and Molecular Biology | 31 | 14% |
| Agricultural and Biological Sciences | 25 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 5% |
| Other | 17 | 8% |
| Unknown | 63 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2022.
All research outputs
#2,902,964
of 24,294,722 outputs
Outputs from Journal for Immunotherapy of Cancer
#779
of 3,248 outputs
Outputs of similar age
#48,692
of 321,136 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#13
of 27 outputs
Altmetric has tracked 24,294,722 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,248 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,136 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.