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A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

Overview of attention for article published in Allergy, Asthma & Clinical Immunology, March 2013
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Title
A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children
Published in
Allergy, Asthma & Clinical Immunology, March 2013
DOI 10.1186/1710-1492-9-10
Pubmed ID
Authors

Ester MM Klaassen, Brenda EJT Thönissen, Guillaume van Eys, Edward Dompeling, Quirijn Jöbsis

Abstract

The aetiology of childhood asthma is complex. An early dysfunction in the immunological development of the innate immune system in combination with environmental factors possibly triggers asthma. CD14 and toll-like receptors are important components of the innate immune system. The aim of this systematic review was to obtain a better insight into the relation between CD14 and toll-like receptors and childhood asthma in Caucasians. We searched PubMed and EMBASE for relevant articles. In total, 44 articles were included. The quality of the selected studies was independently assessed by the first two authors using the Newcastle-Ottawa quality assessment scale. Toll-like receptor 2, toll-like receptor 6, toll-like receptor 9, and toll-like receptor 10 appear to have some association with childhood asthma in Caucasians. The evidence for a relation of CD14 with childhood asthma is limited. In conclusion, there is no convincing evidence yet for a role of CD14 and toll-like receptors in relation to childhood asthma. Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 21%
Student > Bachelor 6 18%
Student > Ph. D. Student 5 15%
Student > Doctoral Student 4 12%
Researcher 4 12%
Other 6 18%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 18%
Biochemistry, Genetics and Molecular Biology 5 15%
Medicine and Dentistry 5 15%
Immunology and Microbiology 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 5 15%
Unknown 8 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2013.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Allergy, Asthma & Clinical Immunology
#784
of 924 outputs
Outputs of similar age
#161,566
of 209,694 outputs
Outputs of similar age from Allergy, Asthma & Clinical Immunology
#8
of 8 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 924 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,694 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.