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Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus

Overview of attention for article published in Arthritis Research & Therapy, January 2013
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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3 tweeters

Citations

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20 Dimensions

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55 Mendeley
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Title
Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4197
Pubmed ID
Authors

Mark W DiFrancesco, Darren R Gitelman, Marisa S Klein-Gitelman, Anna Carmela P Sagcal-Gironella, Frank Zelko, Dean Beebe, Todd Parrish, Jessica Hummel, Jun Ying, Hermine I Brunner

Abstract

INTRODUCTION: Neuropsychiatric manifestations are common in childhood-onset systemic lupus erythematosus (cSLE) and often include neurocognitive dysfunction (NCD). Functional magnetic resonance imaging (fMRI) can measure brain activation during tasks that invoke domains of cognitive function impaired by cSLE. This study investigates specific changes in brain function attributable to NCD in cSLE that have potential to serve as imaging biomarkers. METHODS: Formal neuropsychological testing was done to measure cognitive ability and to identify NCD. Participants performed fMRI tasks probing three cognitive domains impacted by cSLE: visuoconstructional ability (VCA), working memory, and attention. Imaging data, collected on 3-Tesla scanners, included a high-resolution T1-weighted anatomic reference image followed by a T2*-weighted whole-brain echo planar image series for each fMRI task. Brain activation using blood oxygenation level-dependent contrast was compared between cSLE patients with NCD (NCD-group, n = 7) vs. without NCD (noNCD-group, n = 14) using voxel-wise and region of interest-based analyses. The relationship of brain activation during fMRI tasks and performance in formal neuropsychological testing was assessed. RESULTS: Greater brain activation was observed in the noNCD-group vs. NCD-group during VCA and working memory fMRI tasks. Conversely, compared to the noNCD-group, the NCD-group showed more brain activation during the attention fMRI task. In region of interest analysis, brain activity during VCA and working memory fMRI tasks was positively associated with the participants' neuropsychological test performance. In contrast, brain activation during the attention fMRI task was negatively correlated with neuropsychological test performance. While the NCD group performed worse than the noNCD group during VCA and working memory tasks, the attention task was performed equally well by both groups. CONCLUSIONS: NCD in patients with cSLE is characterized by differential activation of functional neuronal networks during fMRI tasks probing working memory, VCA, and attention. Results suggest a compensatory mechanism allows maintenance of attentional performance under NCD. This mechanism appears to break down for the VCA and working memory challenges presented in this study. The observation that neuronal network activation is related to the formal neuropsychological testing performance makes fMRI a candidate imaging biomarker for cSLE-associated NCD.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Singapore 1 2%
Brazil 1 2%
Unknown 51 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 13%
Student > Ph. D. Student 6 11%
Professor 5 9%
Researcher 4 7%
Student > Doctoral Student 4 7%
Other 17 31%
Unknown 12 22%
Readers by discipline Count As %
Medicine and Dentistry 19 35%
Psychology 11 20%
Neuroscience 4 7%
Nursing and Health Professions 2 4%
Engineering 2 4%
Other 4 7%
Unknown 13 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2015.
All research outputs
#7,028,483
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#1,238
of 1,983 outputs
Outputs of similar age
#65,479
of 143,685 outputs
Outputs of similar age from Arthritis Research & Therapy
#4
of 9 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.