Title |
Centering, scaling, and transformations: improving the biological information content of metabolomics data
|
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Published in |
BMC Genomics, June 2006
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DOI | 10.1186/1471-2164-7-142 |
Pubmed ID | |
Authors |
Robert A van den Berg, Huub CJ Hoefsloot, Johan A Westerhuis, Age K Smilde, Mariët J van der Werf |
Abstract |
Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation. For instance, 5000-fold differences in concentration for different metabolites are present in a metabolomics data set, while these differences are not proportional to the biological relevance of these metabolites. However, data analysis methods are not able to make this distinction. Data pretreatment methods can correct for aspects that hinder the biological interpretation of metabolomics data sets by emphasizing the biological information in the data set and thus improving their biological interpretability. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
Canada | 1 | 13% |
Australia | 1 | 13% |
India | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 38% |
Members of the public | 3 | 38% |
Science communicators (journalists, bloggers, editors) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 17 | <1% |
United States | 14 | <1% |
United Kingdom | 11 | <1% |
Spain | 8 | <1% |
Brazil | 7 | <1% |
Portugal | 5 | <1% |
Netherlands | 5 | <1% |
Italy | 4 | <1% |
Canada | 4 | <1% |
Other | 26 | 1% |
Unknown | 2285 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 623 | 26% |
Researcher | 418 | 18% |
Student > Master | 379 | 16% |
Student > Bachelor | 157 | 7% |
Student > Doctoral Student | 133 | 6% |
Other | 294 | 12% |
Unknown | 382 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 566 | 24% |
Chemistry | 367 | 15% |
Biochemistry, Genetics and Molecular Biology | 313 | 13% |
Medicine and Dentistry | 109 | 5% |
Engineering | 95 | 4% |
Other | 429 | 18% |
Unknown | 507 | 21% |