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Effects of external radiation in a co-culture model of endothelial cells and adipose-derived stem cells

Overview of attention for article published in Radiation Oncology, March 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

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2 patents
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1 Facebook page

Citations

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32 Dimensions

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33 Mendeley
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Title
Effects of external radiation in a co-culture model of endothelial cells and adipose-derived stem cells
Published in
Radiation Oncology, March 2013
DOI 10.1186/1748-717x-8-66
Pubmed ID
Authors

Frank Haubner, Michaela Leyh, Elisabeth Ohmann, Fabian Pohl, Lukas Prantl, Holger G Gassner

Abstract

BACKGROUND: The inflammatory response clinically observed after radiation has been described to correlate with elevated expression of cytokines and adhesion molecules by endothelial cells. Therapeutic compensation for this microvascular compromise could be an important approach in the treatment of irradiated wounds. Clinical reports describe the potential of adipose-derived stem cells to enhance wound healing, but the underlying cellular mechanisms remain largely unclear. METHODS: Human dermal microvascular endothelial cells (HDMEC) and human adipose-derived stem cells (ASC) were cultured in a co-culture setting and irradiated with sequential doses of 2 to 12 Gy. Cell count was determined 48 h after radiation using a semi-automated cell counting system. Levels of interleukin-6 (IL-6), basic fibroblast growth factor (FGF), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were determined in the supernatants using enzyme-linked immunosorbent assay (ELISA). Irradiated HDMEC and ASC as well as non-irradiated co-cultures, HDMEC or ASC respectively were used as controls. RESULTS: Cell count was significantly reduced in irradiated co-cultures of HDMEC and ASC compared to non-irradiated controls. Levels of IL-6, FGF, ICAM-1 and VCAM-1 in the supernatants of the co-cultures were significantly less affected by external radiation in comparison to HDMEC. CONCLUSION: The increased expression of cytokines and adhesion molecules by HDMEC after external radiation is mitigated in the co-culture setting with ASC. These in vitro changes seem to support the clinical observation that ASC may have a stabilizing effect when injected into irradiated wounds.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 33%
Researcher 5 15%
Other 2 6%
Student > Bachelor 2 6%
Student > Doctoral Student 2 6%
Other 4 12%
Unknown 7 21%
Readers by discipline Count As %
Medicine and Dentistry 10 30%
Agricultural and Biological Sciences 8 24%
Biochemistry, Genetics and Molecular Biology 3 9%
Engineering 2 6%
Social Sciences 1 3%
Other 1 3%
Unknown 8 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2021.
All research outputs
#4,124,811
of 20,775,181 outputs
Outputs from Radiation Oncology
#160
of 1,920 outputs
Outputs of similar age
#33,720
of 172,095 outputs
Outputs of similar age from Radiation Oncology
#1
of 1 outputs
Altmetric has tracked 20,775,181 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,920 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,095 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them