Title |
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
|
---|---|
Published in |
Alzheimer's Research & Therapy, January 2010
|
DOI | 10.1186/alzrt59 |
Pubmed ID | |
Authors |
Randall J Bateman, Paul S Aisen, Bart De Strooper, Nick C Fox, Cynthia A Lemere, John M Ringman, Stephen Salloway, Reisa A Sperling, Manfred Windisch, Chengjie Xiong |
Abstract |
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | <1% |
Spain | 5 | <1% |
United Kingdom | 2 | <1% |
Singapore | 1 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
Philippines | 1 | <1% |
Unknown | 607 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 118 | 19% |
Student > Bachelor | 86 | 14% |
Researcher | 76 | 12% |
Student > Master | 75 | 12% |
Student > Doctoral Student | 32 | 5% |
Other | 84 | 13% |
Unknown | 153 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 87 | 14% |
Neuroscience | 85 | 14% |
Medicine and Dentistry | 83 | 13% |
Biochemistry, Genetics and Molecular Biology | 80 | 13% |
Psychology | 28 | 4% |
Other | 79 | 13% |
Unknown | 182 | 29% |