You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
| Title |
Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae
|
|---|---|
| Published in |
BMC Biology, March 2013
|
| DOI | 10.1186/1741-7007-11-24 |
| Pubmed ID | |
| Authors |
Michaela de Clare, Stephen G Oliver |
| Abstract |
Copy-number variation (CNV), rather than complete loss of gene function, is increasingly implicated in human disease. Moreover, gene dosage is recognised as important in tumourigenesis, and there is an increasing realisation that CNVs may not be just symptomatic of the cancerous state but may, in fact, be causative. However, the identification of CNV-related phenotypes for mammalian genes is a slow process, due to the technical difficulty of constructing deletion mutants. Using the genome-wide deletion library for the model eukaryote, Saccharomyces cerevisiae, we have identified genes (termed haploproficient, HP) which, when one copy is deleted from a diploid cell, result in an increased rate of proliferation. Since haploproficiency under nutrient-sufficient conditions is a novel phenotype, we sought here to characterise a subset of the yeast haploproficient genes which seem particularly relevant to human cancers. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 27% |
| United Kingdom | 2 | 18% |
| Spain | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 36% |
| Scientists | 3 | 27% |
| Science communicators (journalists, bloggers, editors) | 3 | 27% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Canada | 1 | 1% |
| Singapore | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 70 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 32% |
| Researcher | 15 | 20% |
| Student > Bachelor | 9 | 12% |
| Student > Master | 8 | 11% |
| Student > Doctoral Student | 4 | 5% |
| Other | 14 | 18% |
| Unknown | 2 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 57% |
| Biochemistry, Genetics and Molecular Biology | 16 | 21% |
| Medicine and Dentistry | 5 | 7% |
| Computer Science | 2 | 3% |
| Engineering | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 5 | 7% |