Title |
Potential repurposing of oncology drugs for the treatment of Alzheimer's disease
|
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Published in |
BMC Medicine, March 2013
|
DOI | 10.1186/1741-7015-11-82 |
Pubmed ID | |
Authors |
Wataru Araki |
Abstract |
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia, affecting about 30 million people worldwide. Despite recent advances in understanding its molecular pathology, no mechanism-based drugs are currently available that can halt the progression of AD. Because amyloid-β-peptide (Aβ), a primary component of senile plaques, is thought to be a central pathogenic culprit, several disease-modifying therapies are being developed, including inhibitors of Aβ-producing proteases and immunotherapies with anti-Aβ antibodies. Drug repositioning or repurposing is regarded as a complementary and reasonable approach to identify new drug candidates for AD. This commentary will discuss the clinical relevance of an attractive candidate compound reported in a recent paper by Hayes et al. (BMC Medicine 2013) as well as perspectives regarding the possible repositioning of oncology drugs for the treatment of AD. See related research article here http://www.biomedcentral.com/1741-7015/11/81. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 43% |
Spain | 1 | 14% |
United States | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 18% |
Student > Ph. D. Student | 5 | 18% |
Student > Master | 4 | 14% |
Other | 3 | 11% |
Professor | 2 | 7% |
Other | 3 | 11% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 6 | 21% |
Agricultural and Biological Sciences | 4 | 14% |
Medicine and Dentistry | 4 | 14% |
Neuroscience | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Other | 2 | 7% |
Unknown | 7 | 25% |