↓ Skip to main content

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

Overview of attention for article published in Acta Neuropathologica Communications, October 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 1,574)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
26 news outlets
blogs
1 blog
twitter
13 X users
reddit
1 Redditor

Citations

dimensions_citation
212 Dimensions

Readers on

mendeley
276 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
Published in
Acta Neuropathologica Communications, October 2016
DOI 10.1186/s40478-016-0382-8
Pubmed ID
Authors

Jonathan D. Cherry, Yorghos Tripodis, Victor E. Alvarez, Bertrand Huber, Patrick T. Kiernan, Daniel H. Daneshvar, Jesse Mez, Philip H. Montenigro, Todd M. Solomon, Michael L. Alosco, Robert A. Stern, Ann C. McKee, Thor D. Stein

Abstract

The chronic effects of repetitive head impacts (RHI) on the development of neuroinflammation and its relationship to chronic traumatic encephalopathy (CTE) are unknown. Here we set out to determine the relationship between RHI exposure, neuroinflammation, and the development of hyperphosphorylated tau (ptau) pathology and dementia risk in CTE. We studied a cohort of 66 deceased American football athletes from the Boston University-Veteran's Affairs-Concussion Legacy Foundation Brain Bank as well as 16 non-athlete controls. Subjects with a neurodegenerative disease other than CTE were excluded. Counts of total and activated microglia, astrocytes, and ptau pathology were performed in the dorsolateral frontal cortex (DLF). Binary logistic and simultaneous equation regression models were used to test associations between RHI exposure, microglia, ptau pathology, and dementia. Duration of RHI exposure and the development and severity of CTE were associated with reactive microglial morphology and increased numbers of CD68 immunoreactive microglia in the DLF. A simultaneous equation regression model demonstrated that RHI exposure had a significant direct effect on CD68 cell density (p < 0.0001) and ptau pathology (p < 0.0001) independent of age at death. The effect of RHI on ptau pathology was partially mediated through increased CD68 positive cell density. A binary logistic regression demonstrated that a diagnosis of dementia was significantly predicted by CD68 cell density (OR = 1.010, p = 0.011) independent of age (OR = 1.055, p = 0.007), but this effect disappeared when ptau pathology was included in the model. In conclusion, RHI is associated with chronic activation of microglia, which may partially mediate the effect of RHI on the development of ptau pathology and dementia in CTE. Inflammatory molecules may be important diagnostic or predictive biomarkers as well as promising therapeutic targets in CTE.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 276 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
United Kingdom 1 <1%
Unknown 273 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 50 18%
Student > Ph. D. Student 40 14%
Researcher 32 12%
Student > Master 26 9%
Student > Doctoral Student 18 7%
Other 38 14%
Unknown 72 26%
Readers by discipline Count As %
Neuroscience 64 23%
Medicine and Dentistry 40 14%
Biochemistry, Genetics and Molecular Biology 23 8%
Agricultural and Biological Sciences 21 8%
Psychology 15 5%
Other 33 12%
Unknown 80 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 208. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2024.
All research outputs
#186,768
of 25,374,374 outputs
Outputs from Acta Neuropathologica Communications
#13
of 1,574 outputs
Outputs of similar age
#3,652
of 321,802 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 25 outputs
Altmetric has tracked 25,374,374 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,574 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,802 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.