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Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker

Overview of attention for article published in Alzheimer's Research & Therapy, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

news
2 news outlets
twitter
3 tweeters
patent
2 patents
facebook
1 Facebook page

Citations

dimensions_citation
103 Dimensions

Readers on

mendeley
145 Mendeley
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Title
Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker
Published in
Alzheimer's Research & Therapy, January 2013
DOI 10.1186/alzrt162
Pubmed ID
Authors

Jon B Toledo, Leslie M Shaw, John Q Trojanowski

Abstract

Cerebrospinal fluid and positron emission tomography biomarkers accurately predict an underlying Alzheimer's disease (AD) pathology; however, they represent either invasive or expensive diagnostic tools. Therefore, a blood-based biomarker like plasma amyloid beta (Aβ) that could correlate with the underlying AD pathology and serve as a prognostic biomarker or an AD screening strategy is urgently needed as a cost-effective and non-invasive diagnostic tool. In this paper we review the demographic, biologic, genetic and technical aspects that affect plasma Aβ levels. Findings of cross-sectional and longitudinal studies of plasma Aβ, including autosomal dominant AD cases, sporadic AD cases, Down syndrome cases and population studies, are also discussed. Finally, we review the association between cerebrovascular disease and Aβ plasma levels and the responses observed in clinical trials. Based on our review of the current literature on plasma Aβ, we conclude that further clinical research and assay development are needed before measures of plasma Aβ can be interpreted so they can be applied as trait, risk or state biomarkers for AD.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Korea, Republic of 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 141 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 21%
Student > Ph. D. Student 27 19%
Student > Master 17 12%
Other 13 9%
Student > Bachelor 12 8%
Other 25 17%
Unknown 21 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 21%
Medicine and Dentistry 27 19%
Biochemistry, Genetics and Molecular Biology 22 15%
Neuroscience 14 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 23 16%
Unknown 23 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2019.
All research outputs
#1,112,872
of 17,360,236 outputs
Outputs from Alzheimer's Research & Therapy
#163
of 890 outputs
Outputs of similar age
#10,472
of 161,254 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#2
of 2 outputs
Altmetric has tracked 17,360,236 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 890 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,254 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.