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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, March 2013
|
| DOI | 10.1186/alzrt162 |
| Pubmed ID | |
| Authors |
Jon B Toledo, Leslie M Shaw, John Q Trojanowski |
| Abstract |
Cerebrospinal fluid and positron emission tomography biomarkers accurately predict an underlying Alzheimer's disease (AD) pathology; however, they represent either invasive or expensive diagnostic tools. Therefore, a blood-based biomarker like plasma amyloid beta (Aβ) that could correlate with the underlying AD pathology and serve as a prognostic biomarker or an AD screening strategy is urgently needed as a cost-effective and non-invasive diagnostic tool. In this paper we review the demographic, biologic, genetic and technical aspects that affect plasma Aβ levels. Findings of cross-sectional and longitudinal studies of plasma Aβ, including autosomal dominant AD cases, sporadic AD cases, Down syndrome cases and population studies, are also discussed. Finally, we review the association between cerebrovascular disease and Aβ plasma levels and the responses observed in clinical trials. Based on our review of the current literature on plasma Aβ, we conclude that further clinical research and assay development are needed before measures of plasma Aβ can be interpreted so they can be applied as trait, risk or state biomarkers for AD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Spain | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 154 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 20% |
| Student > Ph. D. Student | 27 | 17% |
| Student > Master | 18 | 11% |
| Student > Bachelor | 14 | 9% |
| Other | 13 | 8% |
| Other | 29 | 18% |
| Unknown | 26 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 20% |
| Medicine and Dentistry | 30 | 19% |
| Biochemistry, Genetics and Molecular Biology | 23 | 15% |
| Neuroscience | 14 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 25 | 16% |
| Unknown | 30 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2019.
All research outputs
#1,811,618
of 25,373,627 outputs
Outputs from Alzheimer's Research & Therapy
#309
of 1,464 outputs
Outputs of similar age
#14,262
of 208,502 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#5
of 9 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,502 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.