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Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems

Overview of attention for article published in Alzheimer's Research & Therapy, January 2013
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter
patent
1 patent
facebook
1 Facebook page

Citations

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48 Dimensions

Readers on

mendeley
96 Mendeley
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Title
Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems
Published in
Alzheimer's Research & Therapy, January 2013
DOI 10.1186/alzrt164
Pubmed ID
Authors

Douglas Galasko, Todd E Golde

Abstract

Substances produced throughout the body are detectable in the blood, which is the most common biological fluid used in clinical testing. Biomarkers for Alzheimer's disease (AD) have long been sought in the blood, but none has become an established or validated diagnostic test. Companion reviews in Alzheimer's Research & Therapy will review specific types of biomarkers or applications; in this overview, we cover key concepts related to AD blood biomarker studies in general. Reasons for the difficulty of detecting markers of a brain-specific disorder, such as AD, in the blood are outlined; these pose conceptual challenges for blood biomarker discovery and development. Applications of blood tests in AD go beyond screening and diagnostic testing; other potential uses are risk assessment, prognostication, and evaluation of treatment target engagement, toxicity, and outcome. Opportunities and questions that may surround these different uses are discussed. A systematic approach to biomarker discovery, detection, assay development and quality control, sample collection, handling and storage, and design and analysis of clinical studies needs to be implemented at every step of discovery and translation to identify an interpretable and useful biomarker.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 95 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 21%
Student > Master 17 18%
Researcher 11 11%
Student > Bachelor 11 11%
Student > Doctoral Student 4 4%
Other 14 15%
Unknown 19 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 18%
Medicine and Dentistry 15 16%
Neuroscience 11 11%
Biochemistry, Genetics and Molecular Biology 9 9%
Chemistry 4 4%
Other 13 14%
Unknown 27 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2021.
All research outputs
#6,923,674
of 22,703,044 outputs
Outputs from Alzheimer's Research & Therapy
#1,015
of 1,204 outputs
Outputs of similar age
#75,767
of 280,698 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#29
of 47 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,204 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.1. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.