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X Demographics
Mendeley readers
| Title |
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio)
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|---|---|
| Published in |
BMC Biology, March 2013
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| DOI | 10.1186/1741-7007-11-26 |
| Pubmed ID | |
| Authors |
Alexander G Little, Tatsuya Kunisue, Kurunthachalam Kannan, Frank Seebacher |
| Abstract |
Thyroid hormone (TH) is best known for its role in development in animals, and for its control of metabolic heat production (thermogenesis) during cold acclimation in mammals. It is unknown whether the regulatory role of TH in thermogenesis is derived in mammals, or whether TH also mediates thermal responses in earlier vertebrates. Ectothermic vertebrates show complex responses to temperature variation, but the mechanisms mediating these are poorly understood. The molecular mechanisms underpinning TH action are very similar across vertebrates, suggesting that TH may also regulate thermal responses in ectotherms. We therefore aimed to determine whether TH regulates thermal acclimation in the zebrafish (Danio rerio). We induced hypothyroidism, followed by supplementation with 3,5-diiodothyronine (T2) or 3,5,3'-triiodothyronine (T3) in zebrafish exposed to different chronic temperatures. We measured whole-animal responses (swimming performance and metabolic rates), tissue-specific regulatory enzyme activities, gene expression, and free levels of T2 and T3. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| Indonesia | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Poland | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 142 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 21% |
| Student > Ph. D. Student | 22 | 15% |
| Student > Bachelor | 19 | 13% |
| Student > Master | 18 | 12% |
| Professor | 7 | 5% |
| Other | 21 | 14% |
| Unknown | 28 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 40% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Environmental Science | 14 | 10% |
| Immunology and Microbiology | 4 | 3% |
| Medicine and Dentistry | 4 | 3% |
| Other | 15 | 10% |
| Unknown | 34 | 23% |