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Chemo-radiotherapy plus durvalumab for loco-regional relapse of resected NSCLC

Overview of attention for article published in Radiation Oncology, July 2022
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1 Redditor

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Title
Chemo-radiotherapy plus durvalumab for loco-regional relapse of resected NSCLC
Published in
Radiation Oncology, July 2022
DOI 10.1186/s13014-022-02084-5
Pubmed ID
Authors

Paolo Borghetti, Jessica Imbrescia, Giulia Volpi, Vieri Scotti, Michele Aquilano, Alessio Bruni, Davide Franceschini, Stefano Ursino, Patrizia Ciammella, Gaia Piperno, Maria Taraborrelli, Stefano Maria Magrini

Abstract

tumor recurrence after NSCLC surgical resection is the most common cause of treatment failure that sharply reduces the patient's life expectancy. The optimal treatment strategy for loco-regional recurrences developing after surgical resection in patients with non-small-cell lung cancer (NSCLC) is not established yet. This report aims to describe the pattern of relapse, PFS, and OS in patients treated with radio-chemotherapy and durvalumab for loco-regional relapse after surgery.  We conducted a multicenter, retrospective study including subjects who underwent surgical resection for NSCLC and were treated with Pacific protocol after loco-regional relapse. Twenty-four patients met the inclusion criteria. At the time of diagnosis mean age was 65 years (range 47-78), the majority being male (58.3%). The 12-month progression-free survival rate was 68.7%, the 18-month progression-free survival rate was 45.8%, and the 24-month progression-free survival rate was 34.3%. There were three deaths: the 12-month survival rate was 91%, and the 18-month survival rate was 82.8%. In this article, we propose a treatment strategy that might prolong post recurrence survival in patients with good performance status experiencing loco-regional relapse after surgery.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 25%
Student > Master 1 25%
Unknown 2 50%
Readers by discipline Count As %
Medicine and Dentistry 2 50%
Unknown 2 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2022.
All research outputs
#15,708,425
of 23,344,526 outputs
Outputs from Radiation Oncology
#1,071
of 2,095 outputs
Outputs of similar age
#241,436
of 436,612 outputs
Outputs of similar age from Radiation Oncology
#21
of 45 outputs
Altmetric has tracked 23,344,526 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,095 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 436,612 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.