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Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis

Overview of attention for article published in BMC Neuroscience, December 2012
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Title
Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis
Published in
BMC Neuroscience, December 2012
DOI 10.1186/1471-2202-13-156
Pubmed ID
Authors

Qinyong Ye, Bixia Huang, Xiaodong Zhang, Yuangui Zhu, Xiaochun Chen

Abstract

Although the etiology of PD remains unclear, increasing evidence has shown that oxidative stress plays an important role in its pathogenesis and that of other neurodegenerative disorders. NOX2, a cytochrome subunit of NOX, transports electrons across the plasma membrane to generate ROS, leading to physiological and pathological processes. Heme oxygenase-1 (HO-1) can be rapidly induced by oxidative stress and other noxious stimuli in the brain or other tissues. Astaxanthin (ATX), a carotenoid with antioxidant properties, is 100-1000 times more effective than vitamin E. The present study investigated the neuroprotective effects of ATX on MPP(+)-induced oxidative stress in PC12 cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 15%
Student > Ph. D. Student 11 14%
Student > Master 11 14%
Student > Bachelor 6 8%
Other 5 6%
Other 11 14%
Unknown 22 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 24%
Biochemistry, Genetics and Molecular Biology 9 12%
Neuroscience 7 9%
Medicine and Dentistry 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 6 8%
Unknown 26 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2013.
All research outputs
#20,187,333
of 22,703,044 outputs
Outputs from BMC Neuroscience
#1,051
of 1,240 outputs
Outputs of similar age
#248,416
of 280,290 outputs
Outputs of similar age from BMC Neuroscience
#20
of 33 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,290 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.