Title |
Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis
|
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Published in |
BMC Neuroscience, December 2012
|
DOI | 10.1186/1471-2202-13-156 |
Pubmed ID | |
Authors |
Qinyong Ye, Bixia Huang, Xiaodong Zhang, Yuangui Zhu, Xiaochun Chen |
Abstract |
Although the etiology of PD remains unclear, increasing evidence has shown that oxidative stress plays an important role in its pathogenesis and that of other neurodegenerative disorders. NOX2, a cytochrome subunit of NOX, transports electrons across the plasma membrane to generate ROS, leading to physiological and pathological processes. Heme oxygenase-1 (HO-1) can be rapidly induced by oxidative stress and other noxious stimuli in the brain or other tissues. Astaxanthin (ATX), a carotenoid with antioxidant properties, is 100-1000 times more effective than vitamin E. The present study investigated the neuroprotective effects of ATX on MPP(+)-induced oxidative stress in PC12 cells. |
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