Title |
Attenuation of cognitive impairment by the nonbacteriolytic antibiotic daptomycin in Wistar rats submitted to pneumococcal meningitis
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Published in |
BMC Neuroscience, April 2013
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DOI | 10.1186/1471-2202-14-42 |
Pubmed ID | |
Authors |
Tatiana Barichello, João Carlos Nepomuceno Gonçalves, Jaqueline S Generoso, Graziele L Milioli, Cintia Silvestre, Caroline S Costa, Jaqueline da Rosa Coelho, Clarissa M Comim, João Quevedo |
Abstract |
Streptococcus pneumoniae is associated with neurologic sequels, such as, seizures, sensory-motor deficits, hearing loss, learning and memory impairment, which can occur in approximately 30 to 52% of surviving patients. Neuronal damage can be caused by intense inflammatory reaction and direct effects of the bacteria virulence factors. The aim of the present study was to evaluate the effects of the nonbacteriolytic antibiotic daptomycin versus ceftriaxone on behavioral parameters in adult Wistar rats submitted to pneumococcal meningitis. |
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