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Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

Overview of attention for article published in BMC Neuroscience, April 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)

Mentioned by

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2 tweeters
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2 patents
reddit
1 Redditor

Citations

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53 Dimensions

Readers on

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81 Mendeley
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Title
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice
Published in
BMC Neuroscience, April 2013
DOI 10.1186/1471-2202-14-44
Pubmed ID
Authors

Sandra Sivilia, Luca Lorenzini, Alessandro Giuliani, Marco Gusciglio, Mercedes Fernandez, Vito Antonio Baldassarro, Chiara Mangano, Luca Ferraro, Vladimiro Pietrini, Maria Francesca Baroc, Arturo R Viscomi, Simone Ottonello, Gino Villetti, Bruno P Imbimbo, Laura Calzà, Luciana Giardino

Abstract

Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibrillary tangles, but the primary cause is only partially understood. Thus, there is growing interest in developing agents that might target multiple mechanisms leading to neuronal degeneration. CHF5074 is a nonsteroidal anti-inflammatory derivative that has been shown to behave as a γ-secretase modulator in vitro and to inhibit plaque deposition and to reverse memory deficit in vivo in transgenic mouse models of Alzheimer's disease (AD). In the present study, the effects of a long-term (13-month) treatment with CHF5074 on indicators of brain functionality and neurodegeneration in transgenic AD mice (Tg2576) have been assessed and compared with those induced by a prototypical γ-secretase inhibitor (DAPT).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Unknown 79 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 21%
Student > Master 16 20%
Student > Ph. D. Student 15 19%
Other 10 12%
Student > Bachelor 5 6%
Other 9 11%
Unknown 9 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 25%
Biochemistry, Genetics and Molecular Biology 11 14%
Medicine and Dentistry 10 12%
Neuroscience 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 6 7%
Other 15 19%
Unknown 12 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2018.
All research outputs
#4,756,431
of 19,274,207 outputs
Outputs from BMC Neuroscience
#229
of 1,169 outputs
Outputs of similar age
#38,881
of 168,748 outputs
Outputs of similar age from BMC Neuroscience
#1
of 1 outputs
Altmetric has tracked 19,274,207 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,169 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,748 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them