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Mendeley readers
Attention Score in Context
| Title |
Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects
|
|---|---|
| Published in |
AIDS Research and Therapy, February 2006
|
| DOI | 10.1186/1742-6405-3-5 |
| Pubmed ID | |
| Authors |
Vishwanath Venketaraman, Tatanisha Rodgers, Rafael Linares, Nancy Reilly, Shobha Swaminathan, David Hom, Ariel C Millman, Robert Wallis, Nancy D Connell |
| Abstract |
Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular M. tuberculosis infection. N-acetyl cysteine treatment decreased the levels of IL-1, TNF-alpha, and IL-6, and increased the levels of IFN-gamma in blood cultures derived from human immunodeficiency virus-infected subjects, promoting the host immune responses to contain M. tuberculosis infection successfully. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 3% |
| United States | 1 | 3% |
| Portugal | 1 | 3% |
| Unknown | 30 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 21% |
| Student > Master | 7 | 21% |
| Researcher | 6 | 18% |
| Other | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 3 | 9% |
| Unknown | 4 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 8 | 24% |
| Medicine and Dentistry | 8 | 24% |
| Agricultural and Biological Sciences | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Economics, Econometrics and Finance | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 5 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2016.
All research outputs
#17,683,485
of 22,703,044 outputs
Outputs from AIDS Research and Therapy
#428
of 547 outputs
Outputs of similar age
#66,515
of 70,516 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 2 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 547 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,516 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.