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Treatment of trauma-affected refugees with venlafaxine versus sertraline combined with psychotherapy - a randomised study

Overview of attention for article published in BMC Psychiatry, November 2016
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3 tweeters
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1 Facebook page

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197 Mendeley
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Title
Treatment of trauma-affected refugees with venlafaxine versus sertraline combined with psychotherapy - a randomised study
Published in
BMC Psychiatry, November 2016
DOI 10.1186/s12888-016-1081-5
Pubmed ID
Authors

Charlotte Sonne, Jessica Carlsson, Per Bech, Ask Elklit, Erik Lykke Mortensen

Abstract

The prevalence of trauma-related psychiatric disorders is high among refugees. Despite this, little is known about the effect of pharmacological treatment for this patient group. The objective of the present study was therefore to examine differences in the effects of venlafaxine and sertraline on Post-Traumatic Stress Disorder (PTSD), depression and functional impairment in trauma-affected refugees. The study was a randomised pragmatic trial comparing venlafaxine and sertraline in combination with psychotherapy and social counselling. PTSD symptoms were measured on the Harvard Trauma Questionnaire - part IV, which was the primary outcome measure. Other outcome measures included: Hopkins Symptom Check List-25 (depression and anxiety), Social Adjustment Scale - short version (social functioning), WHO-5 Well-being Index (quality of life), Crisis Support Scale (support from social network), Sheehan Disability Scale (disability in three areas of functioning), Hamilton Depression and Anxiety scale, the somatisation items of the Symptoms Checklist-90, Global Assessment of Functioning scales and the summarised score of pain in four body areas rated on visual analogue scales. Two hundred seven adult refugee patients were included in the trial (98 in the venlafaxine and 109 in the sertraline group). Of these, 195 patients were eligible for intention-to-treat analyses. Small but significant pre-treatment to post-treatment differences were found on the Harvard Trauma Questionnaire and a number of other ratings in both groups. On the primary outcome measure, no difference was found in treatment effect between the sertraline and venlafaxine group. A significant group difference was found in favour of sertraline on the Sheehan Disability Scale. Sertraline had a slightly better outcome than venlafaxine on some of the secondary outcome measures, but not on the primary outcome measure. Furthermore, a higher percentage of dropouts was found in the venlafaxine group compared to the sertraline group. Although this could indicate that sertraline was better tolerated, which is supported by other studies, a final conclusion on tolerability cannot be drawn from the current study due to lack of systematic reporting of side effects. ClinicalTrials.gov NCT01569685 . Registration date: 28/2/12.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Unknown 196 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 31 16%
Researcher 25 13%
Student > Bachelor 23 12%
Student > Ph. D. Student 22 11%
Student > Doctoral Student 15 8%
Other 31 16%
Unknown 50 25%
Readers by discipline Count As %
Psychology 52 26%
Medicine and Dentistry 45 23%
Nursing and Health Professions 16 8%
Social Sciences 11 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Other 12 6%
Unknown 57 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2017.
All research outputs
#9,137,091
of 15,920,152 outputs
Outputs from BMC Psychiatry
#2,164
of 3,572 outputs
Outputs of similar age
#142,625
of 294,708 outputs
Outputs of similar age from BMC Psychiatry
#221
of 379 outputs
Altmetric has tracked 15,920,152 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,572 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,708 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 379 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.