Title |
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2gene carriers
|
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Published in |
BMC Cancer, March 2013
|
DOI | 10.1186/1471-2407-13-138 |
Pubmed ID | |
Authors |
Emer M Guinan, Juliette Hussey, Sarah A McGarrigle, Laura A Healy, Jacintha N O’Sullivan, Kathleen Bennett, Elizabeth M Connolly |
Abstract |
Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increased. In recent years there has been increased penetrance of BRCA1 and BRCA2 associated breast cancer, prompting investigation into the role of modifiable risk factors in this group. Previous investigations into this topic have relied on participants recalling lifetime weight changes and subjective methods of recording physical activity. The influence of obesity-related biomarkers, which may explain the link between obesity, physical activity and breast cancer risk, has not been investigated prospectively in this group. This paper describes the design of a prospective cohort study investigating the role of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene mutation carriers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 1% |
Unknown | 69 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 20% |
Student > Master | 14 | 20% |
Student > Bachelor | 10 | 14% |
Researcher | 7 | 10% |
Student > Postgraduate | 4 | 6% |
Other | 9 | 13% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 22 | 31% |
Agricultural and Biological Sciences | 10 | 14% |
Nursing and Health Professions | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 7 | 10% |
Unknown | 18 | 26% |