↓ Skip to main content

It takes two to tango in the microenvironment!

Overview of attention for article published in Breast Cancer Research, March 2013
Altmetric Badge

Mentioned by

twitter
1 tweeter
facebook
1 Facebook page

Readers on

mendeley
19 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
It takes two to tango in the microenvironment!
Published in
Breast Cancer Research, March 2013
DOI 10.1186/bcr3388
Pubmed ID
Abstract

Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E2 produced by epithelial cells and, in turn, promoted enhanced migration of epithelial cells. These events in epithelial cells in vitro, including telomere loss, heightened DNA damage response, and activin A expression, are observed in breast ductal carcinoma in situ lesions surrounded by stroma bearing hallmarks of activated fibroblasts and immune and endothelial cell infiltration. Thus, reciprocal epithelial-stromal interactions facilitate progression to malignancy and occur even at the earliest stages of mammary tumorigenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Researcher 3 16%
Student > Master 2 11%
Other 1 5%
Professor 1 5%
Other 4 21%
Unknown 3 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 21%
Agricultural and Biological Sciences 3 16%
Medicine and Dentistry 3 16%
Chemical Engineering 1 5%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 6 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2013.
All research outputs
#12,651,928
of 16,578,610 outputs
Outputs from Breast Cancer Research
#1,347
of 1,698 outputs
Outputs of similar age
#107,568
of 157,617 outputs
Outputs of similar age from Breast Cancer Research
#22
of 25 outputs
Altmetric has tracked 16,578,610 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,698 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,617 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.