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The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life

Overview of attention for article published in Trials, January 2010
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Title
The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life
Published in
Trials, January 2010
DOI 10.1186/1745-6215-11-8
Pubmed ID
Authors

Andrew H Ford, Leon Flicker, Kieran McCaul, Frank van Bockxmeer, Sarah Hegarty, Varsha Hirani, Stephen Fenner, Osvaldo P Almeida

Abstract

Depression is a leading cause of disability worldwide and depressive symptoms are common in later life. Observational evidence suggests that depression is more prevalent among people with high plasma homocysteine (tHcy), but the results of randomized trials to date have been unable to show that lowering tHcy through the supplementation of vitamins B6, B12 and folate benefits depressive symptoms. We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment.

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Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Canada 1 <1%
Unknown 117 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 22 18%
Researcher 20 17%
Student > Ph. D. Student 17 14%
Student > Master 13 11%
Other 8 7%
Other 23 19%
Unknown 16 13%
Readers by discipline Count As %
Medicine and Dentistry 55 46%
Agricultural and Biological Sciences 12 10%
Psychology 11 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Nursing and Health Professions 6 5%
Other 12 10%
Unknown 16 13%