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Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply

Overview of attention for article published in Retrovirology: Research & Treatment, March 2013
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1 tweeter

Citations

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53 Mendeley
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Title
Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply
Published in
Retrovirology: Research & Treatment, March 2013
DOI 10.1186/1742-4690-10-30
Pubmed ID
Authors

Loic Dragin, Laura Anh Nguyen, Hichem Lahouassa, Adèle Sourisce, Baek Kim, Bertha Cecilia Ramirez, Florence Margottin-Goguet

Abstract

Interferon-α (IFN-α) is an essential mediator of the antiviral response, which potently inhibits both early and late phases of HIV replication. The SAMHD1 deoxynucleoside triphosphate (dNTP) hydrolase represents the prototype of a new antiviral strategy we referred to as "nucleotide depletion". SAMHD1 depletes dNTP levels in myeloid cells below those required for optimal synthesis of HIV viral DNA. HIV-2 and its SIVsm and SIVmac close relatives encode a protein termed Vpx, which counteracts SAMHD1. The potentiality of IFN-α to cooperate with nucleotide depletion has been poorly investigated so far. Here we wondered whether IFN-α affects SAMHD1 expression, Vpx-induced SAMHD1 degradation, Vpx-mediated rescue of HIV-1 transduction and the dNTP supply in monocyte-derived macrophages (MDMs).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
Indonesia 1 2%
Puerto Rico 1 2%
Switzerland 1 2%
Unknown 48 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 32%
Researcher 13 25%
Student > Bachelor 7 13%
Professor > Associate Professor 4 8%
Student > Master 4 8%
Other 7 13%
Unknown 1 2%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 43%
Biochemistry, Genetics and Molecular Biology 13 25%
Medicine and Dentistry 7 13%
Immunology and Microbiology 4 8%
Veterinary Science and Veterinary Medicine 1 2%
Other 2 4%
Unknown 3 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2013.
All research outputs
#4,606,338
of 6,228,985 outputs
Outputs from Retrovirology: Research & Treatment
#344
of 450 outputs
Outputs of similar age
#66,012
of 98,427 outputs
Outputs of similar age from Retrovirology: Research & Treatment
#19
of 25 outputs
Altmetric has tracked 6,228,985 research outputs across all sources so far. This one is in the 15th percentile – i.e., 15% of other outputs scored the same or lower than it.
So far Altmetric has tracked 450 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.