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Bovine neonatal pancytopenia - Comparative proteomic characterization of two BVD vaccines and the producer cell surface proteome (MDBK)

Overview of attention for article published in BMC Veterinary Research, January 2013
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Title
Bovine neonatal pancytopenia - Comparative proteomic characterization of two BVD vaccines and the producer cell surface proteome (MDBK)
Published in
BMC Veterinary Research, January 2013
DOI 10.1186/1746-6148-9-18
Pubmed ID
Authors

Kerstin N Euler, Stefanie M Hauck, Marius Ueffing, Cornelia A Deeg

Abstract

Bovine neonatal pancytopenia (BNP) is a disease syndrome in newborn calves of up to four weeks of age, first observed in southern Germany in 2006. By now, cases have been reported in several countries around the globe. Many affected calves die within days due to multiple haemorrhages, thrombocytopenia, leukocytopenia and bone marrow depletion. A certain vaccine directed against Bovine Virus Diarrhoea Virus (BVDV) was recently shown to be associated with BNP pathogenesis. Immunized cows develop alloantibodies that are transferred to newborn calves via colostrum intake. In order to further elucidate BNP pathogenesis, the purpose of this study was to characterize and compare the protein composition of the associated vaccine to another vaccine directed against BVDV not related to BNP and the cell surface proteome of MDBK (Madin-Darby Bovine Kidney) cells, the cell line used for production of the associated vaccine.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 3%
India 1 3%
France 1 3%
Australia 1 3%
Unknown 36 90%

Demographic breakdown

Readers by professional status Count As %
Other 8 20%
Student > Master 6 15%
Student > Bachelor 4 10%
Researcher 4 10%
Student > Ph. D. Student 3 8%
Other 7 18%
Unknown 8 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 33%
Veterinary Science and Veterinary Medicine 7 18%
Medicine and Dentistry 4 10%
Biochemistry, Genetics and Molecular Biology 2 5%
Chemistry 2 5%
Other 4 10%
Unknown 8 20%