↓ Skip to main content

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

Overview of attention for article published in BMC Genomics, January 2011
Altmetric Badge

Mentioned by

twitter
1 X user
facebook
1 Facebook page

Citations

dimensions_citation
322 Dimensions

Readers on

mendeley
614 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
Published in
BMC Genomics, January 2011
DOI 10.1186/1471-2164-12-14
Pubmed ID
Authors

Brady K Atwood, Jacqueline Lopez, James Wager-Miller, Ken Mackie, Alex Straiker

Abstract

G protein coupled receptors (GPCRs) are one of the most widely studied gene superfamilies. Thousands of GPCR research studies have utilized heterologous expression systems such as human embryonic kidney cells (HEK293). Though often treated as 'blank slates', these cell lines nevertheless endogenously express GPCRs and related signaling proteins. The outcome of a given GPCR study can be profoundly influenced by this largely unknown complement of receptors and/or signaling proteins. Little easily accessible information exists that describes the expression profiles of the GPCRs in cell lines. What is accessible is often limited in scope - of the hundreds of GPCRs and related proteins, one is unlikely to find information on expression of more than a dozen proteins in a given cell line. Microarray technology has allowed rapid analysis of mRNA levels of thousands of candidate genes, but though often publicly available, the results can be difficult to efficiently access or even to interpret.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 614 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
Denmark 3 <1%
United Kingdom 2 <1%
Canada 2 <1%
Netherlands 1 <1%
Australia 1 <1%
Ukraine 1 <1%
Belgium 1 <1%
Portugal 1 <1%
Other 4 <1%
Unknown 594 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 152 25%
Researcher 100 16%
Student > Master 76 12%
Student > Bachelor 65 11%
Student > Doctoral Student 31 5%
Other 85 14%
Unknown 105 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 162 26%
Biochemistry, Genetics and Molecular Biology 116 19%
Pharmacology, Toxicology and Pharmaceutical Science 66 11%
Neuroscience 47 8%
Chemistry 39 6%
Other 61 10%
Unknown 123 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2023.
All research outputs
#15,958,140
of 24,287,697 outputs
Outputs from BMC Genomics
#6,417
of 10,940 outputs
Outputs of similar age
#146,665
of 188,203 outputs
Outputs of similar age from BMC Genomics
#65
of 90 outputs
Altmetric has tracked 24,287,697 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,940 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,203 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.