While CD4+ #Tcells are the primary latent reservoir for #HIV1, replication-competent HIV has been detected in #macrophages. During #InVitro HIV infection, a depleted nucleotide pool & high dUTP levels in macrophages leads to proviruses with high dUMP.
New article: Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP https://t.co/Opyf6PrQM5
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP https://t.co/kyBpdlPEyo
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP https://t.co/2JljR5od1O