Title |
The ESR1 gene is associated with risk for canine mammary tumours
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Published in |
BMC Veterinary Research, April 2013
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DOI | 10.1186/1746-6148-9-69 |
Pubmed ID | |
Authors |
Kaja Sverdrup Borge, Malin Melin, Patricio Rivera, Stein Istre Thoresen, Matthew Thomas Webster, Henrik von Euler, Kerstin Lindblad-Toh, Frode Lingaas |
Abstract |
The limited within-breed genetic heterogeneity and an enrichment of disease-predisposing alleles have made the dog a very suitable model for the identification of genes associated with risk for specific diseases. Canine mammary cancer is an example of such a disease. However, the underlying inherited risk factors for canine mammary tumours (CMTs) are still largely unknown. In this study, 52 single nucleotide polymorphisms (SNPs) in ten human cancer-associated genes were genotyped in two different datasets in order to identify genes/alleles associated with the development of CMTs. The first dataset consisted of English Springer Spaniel (ESS) CMT cases and controls. ESS is a dog breed known to be at increased risk of developing CMTs. In the second dataset, dogs from breeds known to have a high frequency of CMTs were compared to dogs from breeds with a lower occurrence of these tumours. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Chile | 1 | 17% |
United States | 1 | 17% |
Brazil | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Sweden | 1 | 2% |
Unknown | 51 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 9 | 17% |
Other | 8 | 15% |
Student > Ph. D. Student | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Researcher | 5 | 9% |
Other | 13 | 25% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 27 | 51% |
Medicine and Dentistry | 10 | 19% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Engineering | 1 | 2% |
Other | 0 | 0% |
Unknown | 6 | 11% |