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Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

Overview of attention for article published in Molecular Neurodegeneration, April 2013
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Mentioned by

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1 tweeter
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1 Facebook page

Citations

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44 Dimensions

Readers on

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83 Mendeley
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Title
Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
Published in
Molecular Neurodegeneration, April 2013
DOI 10.1186/1750-1326-8-12
Pubmed ID
Authors

Buchman VL, Cooper-Knock J, Connor-Robson N, Higginbottom A, Kirby J, Razinskaya OD, Ninkina N, Shaw PJ, Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw

Abstract

Sizing of GGGGCC hexanucleotide repeat expansions within the C9ORF72 locus, which account for approximately 10% of all amyotrophic lateral sclerosis (ALS) cases, is urgently required to answer fundamental questions about mechanisms of pathogenesis in this important genetic variant. Currently employed PCR protocols are limited to discrimination between the presence and absence of a modified allele with more than 30 copies of the repeat, while Southern hybridisation-based methods are confounded by the somatic heterogeneity commonly present in blood samples, which might cause false-negative or ambiguous results.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Austria 1 1%
Canada 1 1%
Unknown 80 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 22%
Researcher 17 20%
Student > Master 10 12%
Student > Bachelor 9 11%
Student > Postgraduate 6 7%
Other 16 19%
Unknown 7 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 30%
Biochemistry, Genetics and Molecular Biology 16 19%
Neuroscience 15 18%
Medicine and Dentistry 13 16%
Psychology 2 2%
Other 3 4%
Unknown 9 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2013.
All research outputs
#3,351,129
of 5,037,615 outputs
Outputs from Molecular Neurodegeneration
#231
of 288 outputs
Outputs of similar age
#58,490
of 93,669 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 5 outputs
Altmetric has tracked 5,037,615 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 288 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,669 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.