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Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza a virus in mice

Overview of attention for article published in Virology Journal, April 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

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1 news outlet
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1 X user

Citations

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22 Dimensions

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44 Mendeley
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Title
Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza a virus in mice
Published in
Virology Journal, April 2013
DOI 10.1186/1743-422x-10-104
Pubmed ID
Authors

Eun-Ha Kim, Jun-Han Lee, Philippe Noriel Q Pascua, Min-Suk Song, Yun-Hee Baek, Hyeok-il Kwon, Su-Jin Park, Gyo-Jin Lim, Arun Decano, Mohammed YE Chowdhury, Su-Kyung Seo, Man Ki Song, Chul-Joong Kim, Young-Ki Choi

Abstract

Influenza vaccines are prepared annually based on global epidemiological surveillance data. However, since there is no method by which to predict the influenza strain that will cause the next pandemic, the demand to develop new vaccination strategies with broad cross-reactivity against influenza viruses are clearly important. The ectodomain of the influenza M2 protein (M2e) is an attractive target for developing a vaccine with broad cross-reactivity. For these reasons, we investigated the efficacy of an inactivated H9N2 virus vaccine (a-H9N2) mixed with M2e (1xM2e or 4xM2e) proteins expressed in Escherichia coli, which contains the consensus of sequence the extracellular domain of matrix 2 (M2e) of A/chicken/Vietnam/27262/09 (H5N1) avian influenza virus, and investigated its humoral immune response and cross-protection against influenza A viruses.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 27%
Researcher 10 23%
Student > Master 7 16%
Lecturer 3 7%
Student > Doctoral Student 2 5%
Other 4 9%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 30%
Medicine and Dentistry 6 14%
Immunology and Microbiology 5 11%
Biochemistry, Genetics and Molecular Biology 3 7%
Veterinary Science and Veterinary Medicine 3 7%
Other 8 18%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2022.
All research outputs
#2,924,951
of 22,705,019 outputs
Outputs from Virology Journal
#272
of 3,031 outputs
Outputs of similar age
#25,488
of 199,814 outputs
Outputs of similar age from Virology Journal
#7
of 67 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,031 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,814 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.