Title |
Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza a virus in mice
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Published in |
Virology Journal, April 2013
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DOI | 10.1186/1743-422x-10-104 |
Pubmed ID | |
Authors |
Eun-Ha Kim, Jun-Han Lee, Philippe Noriel Q Pascua, Min-Suk Song, Yun-Hee Baek, Hyeok-il Kwon, Su-Jin Park, Gyo-Jin Lim, Arun Decano, Mohammed YE Chowdhury, Su-Kyung Seo, Man Ki Song, Chul-Joong Kim, Young-Ki Choi |
Abstract |
Influenza vaccines are prepared annually based on global epidemiological surveillance data. However, since there is no method by which to predict the influenza strain that will cause the next pandemic, the demand to develop new vaccination strategies with broad cross-reactivity against influenza viruses are clearly important. The ectodomain of the influenza M2 protein (M2e) is an attractive target for developing a vaccine with broad cross-reactivity. For these reasons, we investigated the efficacy of an inactivated H9N2 virus vaccine (a-H9N2) mixed with M2e (1xM2e or 4xM2e) proteins expressed in Escherichia coli, which contains the consensus of sequence the extracellular domain of matrix 2 (M2e) of A/chicken/Vietnam/27262/09 (H5N1) avian influenza virus, and investigated its humoral immune response and cross-protection against influenza A viruses. |
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