Title |
JAB1/CSN5: a new player in cell cycle control and cancer
|
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Published in |
Cell Division, October 2010
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DOI | 10.1186/1747-1028-5-26 |
Pubmed ID | |
Authors |
Terry J Shackleford, Francois X Claret |
Abstract |
c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of the constitutive photomorphogenic-9 signalosome (CSN5). Jab1/CSN5 is involved in transcription factor specificity, deneddylation of NEDD8, and nuclear-to-cytoplasmic shuttling of key molecules. Jab1/CSN5 activities positively and negatively affect a number of pathways, including integrin signaling, cell cycle control, and apoptosis. Also, more recent studies have demonstrated the intriguing roles of Jab1/CSN5 in regulating genomic instability and DNA repair. The effects of Jab1/CSN5's multiple protein interactions are generally oncogenic in nature, and overexpression of Jab1/CSN5 in cancer provides evidence that it is involved in the tumorigenic process. In this review, we highlight our current knowledge of Jab1/CSN5 function and the recent discoveries in dissecting the Jab1 signaling pathway. Further, we also discuss the regulation of Jab1/CSN5 in cancers and its potential as a therapeutic target. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 4% |
Portugal | 1 | 1% |
Germany | 1 | 1% |
Unknown | 73 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 24% |
Researcher | 14 | 18% |
Student > Master | 7 | 9% |
Student > Bachelor | 5 | 6% |
Professor > Associate Professor | 4 | 5% |
Other | 12 | 15% |
Unknown | 17 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 44% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Medicine and Dentistry | 3 | 4% |
Unspecified | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 6 | 8% |
Unknown | 18 | 23% |