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JAB1/CSN5: a new player in cell cycle control and cancer

Overview of attention for article published in Cell Division, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 160)
  • Good Attention Score compared to outputs of the same age (78th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
124 Dimensions

Readers on

mendeley
78 Mendeley
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Title
JAB1/CSN5: a new player in cell cycle control and cancer
Published in
Cell Division, October 2010
DOI 10.1186/1747-1028-5-26
Pubmed ID
Authors

Terry J Shackleford, Francois X Claret

Abstract

c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of the constitutive photomorphogenic-9 signalosome (CSN5). Jab1/CSN5 is involved in transcription factor specificity, deneddylation of NEDD8, and nuclear-to-cytoplasmic shuttling of key molecules. Jab1/CSN5 activities positively and negatively affect a number of pathways, including integrin signaling, cell cycle control, and apoptosis. Also, more recent studies have demonstrated the intriguing roles of Jab1/CSN5 in regulating genomic instability and DNA repair. The effects of Jab1/CSN5's multiple protein interactions are generally oncogenic in nature, and overexpression of Jab1/CSN5 in cancer provides evidence that it is involved in the tumorigenic process. In this review, we highlight our current knowledge of Jab1/CSN5 function and the recent discoveries in dissecting the Jab1 signaling pathway. Further, we also discuss the regulation of Jab1/CSN5 in cancers and its potential as a therapeutic target.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
Portugal 1 1%
Germany 1 1%
Unknown 73 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 24%
Researcher 14 18%
Student > Master 7 9%
Student > Bachelor 5 6%
Professor > Associate Professor 4 5%
Other 12 15%
Unknown 17 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 44%
Biochemistry, Genetics and Molecular Biology 13 17%
Medicine and Dentistry 3 4%
Unspecified 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 6 8%
Unknown 18 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2010.
All research outputs
#5,422,599
of 25,373,627 outputs
Outputs from Cell Division
#17
of 160 outputs
Outputs of similar age
#23,116
of 107,836 outputs
Outputs of similar age from Cell Division
#1
of 4 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 160 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,836 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them