Title |
Homozygosity and risk of childhood death due to invasive bacterial disease
|
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Published in |
BMC Medical Genomics, June 2009
|
DOI | 10.1186/1471-2350-10-55 |
Pubmed ID | |
Authors |
Emily J Lyons, William Amos, James A Berkley, Isaiah Mwangi, Mohammed Shafi, Thomas N Williams, Charles R Newton, Norbert Peshu, Kevin Marsh, J Anthony G Scott, Adrian VS Hill |
Abstract |
Genetic heterozygosity is increasingly being shown to be a key predictor of fitness in natural populations, both through inbreeding depression, inbred individuals having low heterozygosity, and also through chance linkage between a marker and a gene under balancing selection. One important component of fitness that is often highlighted is resistance to parasites and other pathogens. However, the significance of equivalent loci in human populations remains unclear. Consequently, we performed a case-control study of fatal invasive bacterial disease in Kenyan children using a genome-wide screen with microsatellite markers. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
Colombia | 1 | 1% |
Tanzania, United Republic of | 1 | 1% |
Canada | 1 | 1% |
Unknown | 78 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 16% |
Student > Ph. D. Student | 12 | 14% |
Student > Bachelor | 11 | 13% |
Student > Master | 9 | 11% |
Professor | 6 | 7% |
Other | 15 | 18% |
Unknown | 17 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 31% |
Medicine and Dentistry | 22 | 27% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Social Sciences | 2 | 2% |
Linguistics | 1 | 1% |
Other | 6 | 7% |
Unknown | 20 | 24% |