Title |
PURE: A webserver for the prediction of domains in unassigned regions in proteins
|
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Published in |
BMC Bioinformatics, June 2008
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DOI | 10.1186/1471-2105-9-281 |
Pubmed ID | |
Authors |
Chilamakuri CS Reddy, Khader Shameer, Bernard O Offmann, Ramanathan Sowdhamini |
Abstract |
Protein domains are the structural and functional units of proteins. The ability to parse proteins into different domains is important for effective classification, understanding of protein structure, function, and evolution and is hence biologically relevant. Several computational methods are available to identify domains in the sequence. Domain finding algorithms often employ stringent thresholds to recognize sequence domains. Identification of additional domains can be tedious involving intense computation and manual intervention but can lead to better understanding of overall biological function. In this context, the problem of identifying new domains in the unassigned regions of a protein sequence assumes a crucial importance. |
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