Title |
Identification of metabolites with anticancer properties by computational metabolomics
|
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Published in |
Molecular Cancer, June 2008
|
DOI | 10.1186/1476-4598-7-57 |
Pubmed ID | |
Authors |
Adrian K Arakaki, Roman Mezencev, Nathan J Bowen, Ying Huang, John F McDonald, Jeffrey Skolnick |
Abstract |
Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD+ and arginine exert this effect by acting as signaling molecules, while carrying out other important cellular functions. Metabolites can also be involved in the control of cell proliferation by directly regulating gene expression in ways that are signaling pathway-independent, e.g. by direct activation of transcription factors or by inducing epigenetic processes. The fact that metabolites can affect the cancer process on so many levels suggests that the change in concentration of some metabolites that occurs in cancer cells could have an active role in the progress of the disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 1% |
United Kingdom | 1 | 1% |
Japan | 1 | 1% |
United States | 1 | 1% |
Luxembourg | 1 | 1% |
Unknown | 76 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 27% |
Student > Ph. D. Student | 16 | 20% |
Professor | 10 | 12% |
Student > Bachelor | 9 | 11% |
Professor > Associate Professor | 4 | 5% |
Other | 13 | 16% |
Unknown | 7 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 38% |
Biochemistry, Genetics and Molecular Biology | 15 | 19% |
Medicine and Dentistry | 9 | 11% |
Chemistry | 5 | 6% |
Engineering | 4 | 5% |
Other | 10 | 12% |
Unknown | 7 | 9% |