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Overview of attention for article published in Immunity & Ageing, January 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 284)
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

1 news outlet
1 blog
41 tweeters
1 Facebook page
1 Wikipedia page
1 video uploader


150 Dimensions

Readers on

173 Mendeley
1 CiteULike
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Published in
Immunity & Ageing, January 2005
DOI 10.1186/1742-4933-2-17
Pubmed ID

V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal, SC Miller


Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natural killer (NK) cells is found with advancing age. Macrophages and granulocytes show functional decline in aging as evidenced by their diminished phagocytic activity and impairment of superoxide generation. There is also marked shift in cytokine profile as age advances, e.g., CD3+ and CD4+ cells decline in number whereas CD8+ cells increase in elderly individuals. A decline in organ specific antibodies occurs causing reduced humoral responsiveness. Circulating melatonin decreases with age and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes-macrophages. It also stimulates the production of NK cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from NK cells and T-helper lymphocytes also are enhanced by melatonin. Melatonin presumably regulates immune function by acting on the immune-opioid network, by affecting G protein-cAMP signal pathway and by regulating intracellular glutathione levels. Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state.

Twitter Demographics

The data shown below were collected from the profiles of 41 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 1%
India 2 1%
Brazil 2 1%
Indonesia 1 <1%
United Kingdom 1 <1%
Italy 1 <1%
Mexico 1 <1%
China 1 <1%
Spain 1 <1%
Other 2 1%
Unknown 159 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 17%
Student > Ph. D. Student 27 16%
Student > Bachelor 23 13%
Student > Master 19 11%
Student > Doctoral Student 15 9%
Other 35 20%
Unknown 24 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 30%
Medicine and Dentistry 38 22%
Biochemistry, Genetics and Molecular Biology 23 13%
Immunology and Microbiology 9 5%
Neuroscience 5 3%
Other 19 11%
Unknown 27 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2021.
All research outputs
of 17,891,883 outputs
Outputs from Immunity & Ageing
of 284 outputs
Outputs of similar age
of 164,246 outputs
Outputs of similar age from Immunity & Ageing
of 1 outputs
Altmetric has tracked 17,891,883 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 284 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,246 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them