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High resolution melting analysis of KRAS, BRAF and PIK3CA in KRASexon 2 wild-type metastatic colorectal cancer

Overview of attention for article published in BMC Cancer, April 2013
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  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
75 Mendeley
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Title
High resolution melting analysis of KRAS, BRAF and PIK3CA in KRASexon 2 wild-type metastatic colorectal cancer
Published in
BMC Cancer, April 2013
DOI 10.1186/1471-2407-13-169
Pubmed ID
Authors

Joana G Guedes, Isabel Veiga, Patrícia Rocha, Pedro Pinto, Carla Pinto, Manuela Pinheiro, Ana Peixoto, Maria Fragoso, Ana Raimundo, Paula Ferreira, Manuela Machado, Nuno Sousa, Paula Lopes, António Araújo, Joana Macedo, Fernando Alves, Camila Coutinho, Rui Henrique, Lúcio L Santos, Manuel R Teixeira

Abstract

KRAS is an EGFR effector in the RAS/RAF/ERK cascade that is mutated in about 40% of metastatic colorectal cancer (mCRC). Activating mutations in codons 12 and 13 of the KRAS gene are the only established negative predictors of response to anti-EGFR therapy and patients whose tumors harbor such mutations are not candidates for therapy. However, 40 to 60% of wild-type cases do not respond to anti-EGFR therapy, suggesting the involvement of other genes that act downstream of EGFR in the RAS-RAF-MAPK and PI3K-AKT pathways or activating KRAS mutations at other locations of the gene.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 1%
Austria 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 25%
Other 12 16%
Student > Ph. D. Student 9 12%
Student > Master 8 11%
Professor 4 5%
Other 12 16%
Unknown 11 15%
Readers by discipline Count As %
Medicine and Dentistry 35 47%
Agricultural and Biological Sciences 16 21%
Biochemistry, Genetics and Molecular Biology 7 9%
Neuroscience 2 3%
Arts and Humanities 1 1%
Other 3 4%
Unknown 11 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2013.
All research outputs
#12,390,469
of 21,346,377 outputs
Outputs from BMC Cancer
#2,643
of 7,668 outputs
Outputs of similar age
#89,664
of 175,138 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
Altmetric has tracked 21,346,377 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,668 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,138 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them