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TfAP-2 is required for night sleep in Drosophila

Overview of attention for article published in BMC Neuroscience, November 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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Title
TfAP-2 is required for night sleep in Drosophila
Published in
BMC Neuroscience, November 2016
DOI 10.1186/s12868-016-0306-3
Pubmed ID
Authors

Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata, Henrik Bringmann

Abstract

The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been linked to sleep disorders. These data suggest that AP-2 transcription factors may be highly conserved regulators of various types of sleep behavior. Here, we tested the idea that AP-2 controls adult sleep in Drosophila. Drosophila has one AP-2 ortholog called TfAP-2, which is essential for viability. To investigate its potential role in sleep behavior and neural development, we specifically downregulated TfAP-2 in the nervous system. We found that neuronal TfAP-2 knockdown almost completely abolished night sleep but did not affect day sleep. TfAP-2 insufficiency affected nervous system development. Conditional TfAP-2 knockdown in the adult also produced a modest sleep phenotype, suggesting that TfAP-2 acts both in larval as well as in differentiated neurons. Thus, our results show that AP-2 transcription factors are highly conserved regulators of development and sleep.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Australia 1 3%
Unknown 31 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 18%
Researcher 6 18%
Student > Master 4 12%
Student > Bachelor 3 9%
Student > Doctoral Student 2 6%
Other 3 9%
Unknown 9 27%
Readers by discipline Count As %
Neuroscience 7 21%
Agricultural and Biological Sciences 5 15%
Biochemistry, Genetics and Molecular Biology 4 12%
Medicine and Dentistry 3 9%
Nursing and Health Professions 2 6%
Other 3 9%
Unknown 9 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2023.
All research outputs
#5,653,767
of 23,507,888 outputs
Outputs from BMC Neuroscience
#245
of 1,262 outputs
Outputs of similar age
#84,121
of 314,799 outputs
Outputs of similar age from BMC Neuroscience
#7
of 20 outputs
Altmetric has tracked 23,507,888 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,262 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,799 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.