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The Scottish Early Rheumatoid Arthritis (SERA) Study: an inception cohort and biobank

Overview of attention for article published in BMC Musculoskeletal Disorders, November 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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Title
The Scottish Early Rheumatoid Arthritis (SERA) Study: an inception cohort and biobank
Published in
BMC Musculoskeletal Disorders, November 2016
DOI 10.1186/s12891-016-1318-y
Pubmed ID
Authors

James Dale, Caron Paterson, Ann Tierney, Stuart H. Ralston, David M. Reid, Neil Basu, John Harvie, Neil D. McKay, Sarah Saunders, Hilary Wilson, Robin Munro, Ruth Richmond, Derek Baxter, Michael McMahon, John McLaren, Vinod Kumar, Stefan Siebert, Iain McInnes, Duncan Porter

Abstract

The Scottish Early Rheumatoid Arthritis (SERA) study is an inception cohort of rheumatoid (RA) and undifferentiated arthritis (UA) patients that aims to provide a contemporary description of phenotype and outcome and facilitate discovery of phenotypic and prognostic biomarkers METHODS: Demographic and clinical outcome data are collected from newly diagnosed RA/UA patients every 6 months from around Scotland. Health service utilization data is acquired from Information Services Division, NHS National Services Scotland. Plain radiographs of hands and feet are collected at baseline and 12 months. Additional samples of whole blood, plasma, serum and filtered urine are collected at baseline, 6 and 12 months RESULTS: Results are available for 1073 patients; at baseline, 76 % were classified as RA and 24 % as UA. Median time from onset to first review was 163 days (IQR97-323). Methotrexate was first-line DMARD for 75 % patients. Disease activity, functional ability and health-related quality of life improved significantly between baseline and 24 months, however the proportion in any employment fell (51 to 38 %, p = 0.0005). 24 % patients reported symptoms of anxiety and/or depression at baseline. 35/391 (9 %) patients exhibited rapid radiographic progression after 12 months. The SERA Biobank has accrued 60,612 samples CONCLUSIONS: In routine care, newly diagnosed RA/UA patients experience significant improvements in disease activity, functional ability and health-related quality of life but have high rates of psychiatric symptoms and declining employment rates. The co-existence of a multi-domain description of phenotype and a comprehensive biobank will facilitate multi-platform translational research to identify predictive markers of phenotype and prognosis.

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The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 1%
Singapore 1 1%
Canada 1 1%
Unknown 81 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 15%
Student > Ph. D. Student 12 14%
Other 10 12%
Student > Master 6 7%
Student > Bachelor 6 7%
Other 16 19%
Unknown 21 25%
Readers by discipline Count As %
Medicine and Dentistry 26 31%
Biochemistry, Genetics and Molecular Biology 7 8%
Nursing and Health Professions 5 6%
Agricultural and Biological Sciences 4 5%
Immunology and Microbiology 3 4%
Other 9 11%
Unknown 30 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2016.
All research outputs
#4,450,525
of 22,901,818 outputs
Outputs from BMC Musculoskeletal Disorders
#883
of 4,062 outputs
Outputs of similar age
#75,108
of 313,012 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#16
of 57 outputs
Altmetric has tracked 22,901,818 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,062 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.