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Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's - derived fibroblasts

Overview of attention for article published in BMC Musculoskeletal Disorders, May 2011
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Title
Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's - derived fibroblasts
Published in
BMC Musculoskeletal Disorders, May 2011
DOI 10.1186/1471-2474-12-113
Pubmed ID
Authors

Latha Satish, Phillip H Gallo, Mark E Baratz, Sandra Johnson, Sandeep Kathju

Abstract

Myofibroblasts, a derived subset of fibroblasts especially important in scar formation and wound contraction, have been found at elevated levels in affected Dupuytren's tissues. Transformation of fibroblasts to myofibroblasts is characterized by expression of alpha- smooth muscle actin (α-SMA) and increased production of extracellular matrix (ECM) components, both events of relevance to connective tissue remodeling. We propose that increasing the activation of the cyclic AMP (cAMP)/protein kinase A signaling pathway will inhibit transforming growth factor-beta1 (TGF-β1)-induced ECM synthesis and myofibroblast formation and may provide a means to blunt fibrosis.

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Switzerland 1 1%
Unknown 77 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 19%
Student > Master 15 19%
Researcher 12 15%
Other 6 8%
Student > Postgraduate 5 6%
Other 13 16%
Unknown 14 18%
Readers by discipline Count As %
Medicine and Dentistry 30 38%
Biochemistry, Genetics and Molecular Biology 12 15%
Agricultural and Biological Sciences 11 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Engineering 2 3%
Other 8 10%
Unknown 15 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2013.
All research outputs
#13,308,039
of 17,351,915 outputs
Outputs from BMC Musculoskeletal Disorders
#2,334
of 3,281 outputs
Outputs of similar age
#111,732
of 162,156 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#1
of 1 outputs
Altmetric has tracked 17,351,915 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,281 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,156 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them