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Mendeley readers
Attention Score in Context
| Title |
Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's - derived fibroblasts
|
|---|---|
| Published in |
BMC Musculoskeletal Disorders, May 2011
|
| DOI | 10.1186/1471-2474-12-113 |
| Pubmed ID | |
| Authors |
Latha Satish, Phillip H Gallo, Mark E Baratz, Sandra Johnson, Sandeep Kathju |
| Abstract |
Myofibroblasts, a derived subset of fibroblasts especially important in scar formation and wound contraction, have been found at elevated levels in affected Dupuytren's tissues. Transformation of fibroblasts to myofibroblasts is characterized by expression of alpha- smooth muscle actin (α-SMA) and increased production of extracellular matrix (ECM) components, both events of relevance to connective tissue remodeling. We propose that increasing the activation of the cyclic AMP (cAMP)/protein kinase A signaling pathway will inhibit transforming growth factor-beta1 (TGF-β1)-induced ECM synthesis and myofibroblast formation and may provide a means to blunt fibrosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 19% |
| Student > Master | 16 | 18% |
| Researcher | 12 | 14% |
| Student > Bachelor | 5 | 6% |
| Student > Postgraduate | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 34% |
| Biochemistry, Genetics and Molecular Biology | 13 | 15% |
| Agricultural and Biological Sciences | 11 | 13% |
| Unspecified | 3 | 3% |
| Engineering | 3 | 3% |
| Other | 9 | 10% |
| Unknown | 19 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2023.
All research outputs
#6,944,560
of 23,245,494 outputs
Outputs from BMC Musculoskeletal Disorders
#1,345
of 4,128 outputs
Outputs of similar age
#38,090
of 113,096 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#14
of 42 outputs
Altmetric has tracked 23,245,494 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,128 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,096 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.