Title |
Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet
|
---|---|
Published in |
BMC Biology, August 2009
|
DOI | 10.1186/1741-7007-7-47 |
Pubmed ID | |
Authors |
Vincent Corbel, Maria Stankiewicz, Cédric Pennetier, Didier Fournier, Jure Stojan, Emmanuelle Girard, Mitko Dimitrov, Jordi Molgó, Jean-Marc Hougard, Bruno Lapied |
Abstract |
N,N-Diethyl-3-methylbenzamide (deet) remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have been applied over the past 50 years. Despite the widespread and increased interest in the use of deet in public health programmes, controversies remain concerning both the identification of its target sites at the olfactory system and its mechanism of toxicity in insects, mammals and humans. Here, we investigated the molecular target site for deet and the consequences of its interactions with carbamate insecticides on the cholinergic system. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Turkey | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
France | 2 | <1% |
Ireland | 1 | <1% |
Mexico | 1 | <1% |
Egypt | 1 | <1% |
Unknown | 198 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 37 | 18% |
Researcher | 37 | 18% |
Student > Master | 26 | 13% |
Student > Bachelor | 20 | 10% |
Student > Postgraduate | 9 | 4% |
Other | 31 | 15% |
Unknown | 46 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 72 | 35% |
Chemistry | 14 | 7% |
Environmental Science | 13 | 6% |
Neuroscience | 13 | 6% |
Medicine and Dentistry | 11 | 5% |
Other | 33 | 16% |
Unknown | 50 | 24% |