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Chemical consequences of cutaneous photoageing

Overview of attention for article published in Chemistry Central Journal, April 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

blogs
1 blog
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
52 Mendeley
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Title
Chemical consequences of cutaneous photoageing
Published in
Chemistry Central Journal, April 2012
DOI 10.1186/1752-153x-6-34
Pubmed ID
Authors

Sarah A Thurstan, Neil K Gibbs, Abigail K Langton, Christopher EM Griffiths, Rachel EB Watson, Michael J Sherratt

Abstract

Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In particular, both the severity and speed of onset of age-related changes, such as wrinkle formation and loss of elasticity, are enhanced in photoaged (also termed extrinsically aged) as compared with aged, photoprotected, skin. The anatomy of skin is characterised by two major layers: an outer, avascular, yet highly cellular and dynamic epidermis and an underlying vascularised, comparatively static and cell-poor, dermis. The structural consequences of photoageing are mainly evident in the extracellular matrix-rich but cell-poor dermis where key extracellular matrix proteins are particularly susceptible to photodamage. Most investigations to date have concentrated on the cell as both a target for and mediator of, ultraviolet radiation-induced photoageing. As the main effectors of dermal remodelling produced by cells (extracellular proteases) generally have low substrate specificity, we recently suggested that the differential susceptibility of key extracellular matrix proteins to the processes of photoageing may be due to direct, as opposed to cell-mediated, photodamage.In this review, we discuss the experimental evidence for ultraviolet radiation (and related reactive oxygen species)-mediated differential degradation of normally long lived dermal proteins including the fibrillar collagens, elastic fibre components, glycoproteins and proteoglycans. Whilst these components exhibit highly diverse primary and hence macro- and supra-molecular structures, we present evidence that amino acid composition alone may be a useful predictor of age-related protein degradation in both photoexposed and, as a consequence of differential oxidation sensitivity, photoprotected, tissues.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Italy 1 2%
France 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 17%
Researcher 8 15%
Other 6 12%
Student > Postgraduate 5 10%
Lecturer 3 6%
Other 8 15%
Unknown 13 25%
Readers by discipline Count As %
Medicine and Dentistry 12 23%
Agricultural and Biological Sciences 9 17%
Biochemistry, Genetics and Molecular Biology 6 12%
Pharmacology, Toxicology and Pharmaceutical Science 6 12%
Psychology 2 4%
Other 4 8%
Unknown 13 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2020.
All research outputs
#1,699,616
of 12,429,455 outputs
Outputs from Chemistry Central Journal
#66
of 569 outputs
Outputs of similar age
#20,679
of 144,549 outputs
Outputs of similar age from Chemistry Central Journal
#1
of 2 outputs
Altmetric has tracked 12,429,455 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 569 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,549 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them