Title |
Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer
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Published in |
BMC Cancer, February 2013
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DOI | 10.1186/1471-2407-13-84 |
Pubmed ID | |
Authors |
Jolien Heukelom, Olga Hamming, Harry Bartelink, Frank Hoebers, Jordi Giralt, Teresa Herlestam, Marcel Verheij, Michiel van den Brekel, Wouter Vogel, Nick Slevin, Eric Deutsch, Jan-Jakob Sonke, Philippe Lambin, Coen Rasch |
Abstract |
Failure of locoregional control is the main cause of recurrence in advanced head and neck cancer. This multi-center trial aims to improve outcome in two ways. Firstly, by redistribution of the radiation dose to the metabolically most FDG-PET avid part of the tumour. Hereby, a biologically more effective dose distribution might be achieved while simultaneously sparing normal tissues. Secondly, by improving patient selection. Both cisplatin and Epidermal Growth Factor Receptor (EGFR) antibodies like Cetuximab in combination with Radiotherapy (RT) are effective in enhancing tumour response. However, it is unknown which patients will benefit from either agent in combination with irradiation. We will analyze the predictive value of biological markers and (89)Zr-Cetuximab uptake for treatment outcome of chemoradiation with Cetuximab or cisplatin to improve patient selection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
France | 1 | <1% |
Unknown | 139 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 14% |
Student > Master | 18 | 13% |
Other | 16 | 11% |
Researcher | 15 | 11% |
Student > Bachelor | 15 | 11% |
Other | 30 | 21% |
Unknown | 27 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 38% |
Physics and Astronomy | 18 | 13% |
Nursing and Health Professions | 8 | 6% |
Agricultural and Biological Sciences | 5 | 4% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Other | 11 | 8% |
Unknown | 41 | 29% |