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Achievements and challenges in bioartificial kidney development

Overview of attention for article published in Fibrogenesis & Tissue Repair, August 2010
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
wikipedia
1 Wikipedia page

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
77 Mendeley
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Title
Achievements and challenges in bioartificial kidney development
Published in
Fibrogenesis & Tissue Repair, August 2010
DOI 10.1186/1755-1536-3-14
Pubmed ID
Authors

Farah Tasnim, Rensheng Deng, Min Hu, Sean Liour, Yao Li, Ming Ni, Jackie Y Ying, Daniele Zink

Abstract

Bioartificial kidneys (BAKs) combine a conventional hemofilter in series with a bioreactor unit containing renal epithelial cells. The epithelial cells derived from the renal tubule should provide transport, metabolic, endocrinologic and immunomodulatory functions. Currently, primary human renal proximal tubule cells are most relevant for clinical applications. However, the use of human primary cells is associated with many obstacles, and the development of alternatives and an unlimited cell source is one of the most urgent challenges. BAKs have been applied in Phase I/II and Phase II clinical trials for the treatment of critically ill patients with acute renal failure. Significant effects on cytokine concentrations and long-term survival were observed. A subsequent Phase IIb clinical trial was discontinued after an interim analysis, and these results showed that further intense research on BAK-based therapies for acute renal failure was required. Development of BAK-based therapies for the treatment of patients suffering from end-stage renal disease is even more challenging, and related problems and research approaches are discussed herein, along with the development of mobile, portable, wearable and implantable devices.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United States 1 1%
Germany 1 1%
Unknown 74 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Student > Bachelor 16 21%
Student > Master 14 18%
Researcher 10 13%
Other 5 6%
Other 10 13%
Unknown 5 6%
Readers by discipline Count As %
Engineering 23 30%
Medicine and Dentistry 11 14%
Agricultural and Biological Sciences 10 13%
Biochemistry, Genetics and Molecular Biology 9 12%
Chemistry 4 5%
Other 14 18%
Unknown 6 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2020.
All research outputs
#965,714
of 19,571,131 outputs
Outputs from Fibrogenesis & Tissue Repair
#1
of 81 outputs
Outputs of similar age
#6,513
of 131,050 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#1
of 1 outputs
Altmetric has tracked 19,571,131 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 81 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 131,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them