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Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives

Overview of attention for article published in BMC Chemistry, April 2013
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Title
Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives
Published in
BMC Chemistry, April 2013
DOI 10.1186/1752-153x-7-68
Pubmed ID
Authors

Sadia Rehman, Muhammad Ikram, Robert J Baker, Muhammad Zubair, Effat Azad, Soyoung Min, Kashif Riaz, KH Mok, Saeed-Ur Rehman

Abstract

Coumarin and its derivatives are biologically very active. It was found that the enhanced activities are dependent on the coumarin nucleus. Biological significance of these compounds include anti-bacterial, anti-thrombotic and vasodilatory, anti-mutagenic, lipoxygenase and cyclooxygenase inhibition, scavenging of reactive oxygen species, and anti-tumourigenic. Our interest in medicinal chemistry of dicoumarol compounds have been developed by keeping in view the importance of coumarins along with its derivatives in medicinal chemistry. All the synthesized compounds were fully characterized by spectroscopic and analytical techniques and were screened for antimicrobial and U2OS bone cancer activities.

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Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 18%
Student > Postgraduate 3 11%
Professor > Associate Professor 3 11%
Student > Master 3 11%
Student > Bachelor 2 7%
Other 7 25%
Unknown 5 18%
Readers by discipline Count As %
Chemistry 9 32%
Agricultural and Biological Sciences 3 11%
Biochemistry, Genetics and Molecular Biology 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Medicine and Dentistry 2 7%
Other 4 14%
Unknown 6 21%