Title |
Consistent high concentration of the viral microRNA BART17 in plasma samples from nasopharyngeal carcinoma patients - evidence of non-exosomal transport
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Published in |
Virology Journal, April 2013
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DOI | 10.1186/1743-422x-10-119 |
Pubmed ID | |
Authors |
Claire Gourzones, François-Régis Ferrand, Corinne Amiel, Benjamin Vérillaud, Ana Barat, Maryse Guérin, Charles-Henry Gattolliat, Aurore Gelin, Jihène Klibi, Arij Ben Chaaben, Véronique Schneider, Fethi Guemira, Joël Guigay, Philippe Lang, Anne-Sophie Jimenez-Pailhes, Pierre Busson |
Abstract |
Because latent Epstein Barr (EBV)-infection is a specific characteristic of malignant nasopharyngeal carcinoma (NPC), various molecules of viral origin are obvious candidate biomarkers in this disease. In a previous study, we could show in a few clinical samples that it was possible to detect a category of EBV microRNAs called miR-BARTs in the plasma of at least a fraction of NPC patients. The first aim of the present study was to investigate the status of circulating miR-BART17-5p (one of the miR-BARTs hereafter called miR-BART17) and EBV DNA in a larger series of NPC plasma samples. The second aim was to determine whether or not circulating miR-BART17 was carried by plasma exosomes. |
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Geographical breakdown
Country | Count | As % |
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France | 2 | 50% |
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
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India | 1 | 1% |
Unknown | 72 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 27% |
Researcher | 14 | 19% |
Student > Bachelor | 8 | 11% |
Other | 6 | 8% |
Professor > Associate Professor | 6 | 8% |
Other | 12 | 16% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 23 | 32% |
Agricultural and Biological Sciences | 17 | 23% |
Biochemistry, Genetics and Molecular Biology | 14 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Neuroscience | 3 | 4% |
Other | 3 | 4% |
Unknown | 10 | 14% |