Title |
AllerTOP - a server for in silico prediction of allergens
|
---|---|
Published in |
BMC Bioinformatics, April 2013
|
DOI | 10.1186/1471-2105-14-s6-s4 |
Pubmed ID | |
Authors |
Ivan Dimitrov, Darren R Flower, Irini Doytchinova |
Abstract |
Allergy is a form of hypersensitivity to normally innocuous substances, such as dust, pollen, foods or drugs. Allergens are small antigens that commonly provoke an IgE antibody response. There are two types of bioinformatics-based allergen prediction. The first approach follows FAO/WHO Codex alimentarius guidelines and searches for sequence similarity. The second approach is based on identifying conserved allergenicity-related linear motifs. Both approaches assume that allergenicity is a linearly coded property. In the present study, we applied ACC pre-processing to sets of known allergens, developing alignment-independent models for allergen recognition based on the main chemical properties of amino acid sequences. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 213 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 13% |
Student > Ph. D. Student | 19 | 9% |
Researcher | 16 | 8% |
Student > Master | 16 | 8% |
Professor > Associate Professor | 6 | 3% |
Other | 21 | 10% |
Unknown | 107 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 44 | 21% |
Agricultural and Biological Sciences | 12 | 6% |
Immunology and Microbiology | 12 | 6% |
Medicine and Dentistry | 6 | 3% |
Engineering | 6 | 3% |
Other | 15 | 7% |
Unknown | 118 | 55% |